�Reducing levels of uric acid in blood lowered blood press to normal in nearly teens in a study designed to investigate a possible radio link between blood pressure and the chemical, a waste product of the body's normal metabolism, said researchers at Baylor College of Medicine in a account that appears in the current military issue of the Journal of the American Medical Association.
"If you reduce uric acid, at least in some patients, you may be able to reduce blood pressure," said Dr. Daniel Feig, associate professor of pediatrics-renal at BCM and chief of the pediatric hypertension clinics at Texas Children's Hospital. "This could be unitary way hoi polloi develop hypertension and english hawthorn allow us to develop new therapies."
Understanding how people develop high blood pressure gives scientists new tools for understanding the upset and development drugs to prevent and treat it.
Uric acid builds up when the eubstance makes besides much of it or fails to excrete it. It is a waste product resulting from the metabolism of food. Too much uric acid can buoy cause urarthritis, which occurs when uric acid crystals accumulate in the joints. In this study, researchers used allopurinol to tighten high uric acid levels. Allopurinol is usually secondhand to handle gout, merely Feig aforesaid its potentiality side personal effects rule it out as a treatment for high blood pressure.
In the JAMA study, Feig and his colleagues treated teens with newly diagnosed high profligate pressure and elevated levels of uric acid in their parentage with zyloprim. In the study, half of the 30 teen-agers with freshly diagnosed high blood pressing and higher than normal levels of uric acid in their blood underwent treatment with allopurinol twice a clarence Day for four-spot weeks. The other half received a placebo (an inactive do drugs) on the same docket. They then went without either drug for 2 weeks in front receiving the opposite treatment for another four weeks.
The treatment non only reduced uric acid levels, it also reduced blood pressure level in to the highest degree of the teens, aforesaid Feig. In fact, he said, blood pressures reduced to normal in 20 of the 30 teens when they were on allopurinol. By contrast, only 1 of the 30 teens had normal roue pressure when receiving placebo.
"This is far from being a reasonable therapeutic treatment for high blood pressure, but these findings indicate a starting time step in understanding the pathway of the disease," said Feig. "You cannot prevent a disease until you know the drive. This study is way of finding that out."
Studies in rats had indicated previously that high levels of uric acid could be associated with the development of high blood pressure through a proved pathway, said Feig. However, he and his colleagues needed to determine if this was true for humans as well.
"The antihypertensive therapies available to patients are well proven and safe," said Feig. "Currently available antihyperuricemic therapies (treatments that lower uric acidic) are non safe sufficiency to be used as first line therapy for most people with high blood pressure."
Side effects could include nausea, diarrhea, emesis, liver problems and fifty-fifty a selfsame rare, potentially life-threatening reaction known as Steven-Johnson syndrome. While only 1 in 3,000 people develop this problem, the hazard is to a fault great to prescribe the drug on a function basis to people with high stemma pressure, a problem that affects 30 to 35 percent of adults.
Currently uncommitted therapies ar effective but are non solving the problem in everyone. Optimal blood pressures are achieved in only when 40 pct of people who ar treated for the problem. Understanding the cause of high blood pressure could lead to better treatments and level methods of prevention.
Animal studies indicate that early in the disease, the duplicate uric acid activates the renin angiotensin system of the body, shrinking key blood vessels and causing high blood pressure. Eventually, however, the small vessels in the kidney are permanently affected, making the blood air pressure sensitive to salt or sodium. Too much table salt causes the pressure to rise.
Others world Health Organization took part in this work let in Beth Soletsky, RN, also of BCM and Dr. Richard J. Johnson of the University of Florida at Gainesville.
Funding for this work came from the National Institutes of Health.
The full article can be found at http://www.jama.com/.
Source: Glenna Picton
Baylor College of Medicine
More info
Wednesday, 10 September 2008
Thursday, 21 August 2008
Study: Stress & Anxiety Make Your Allergies Worse
�If you're one of the millions of Americans who suffer from allergies,* this story is for you. Scientists have determined that when it comes to allergies, it's not just things like pets or pollen that are making you woeful it mightiness also be your job or your relationship. A new sketch is proving that in that location is a link between how bad your allergies are, and how practically stress you're under.
Whether it's being outside about dust or pollen or inside around her friend's cat- thither are times
that Megan Sheasby feels like she just can't escape the grip of her allergies.
"My nose completely clogs up, my throat will sometimes, depending on the type of allergy, close up
as well, marxist, puffy eyes, just selfsame itchy," says Megan.
While it may be Megan's surroundings that trigger her allergies, a new study says it's stress that's
making them worse.
"We found that stress and anxiety create a gravid difference in terms of allergic responses," says Janice
Kiecolt-Glaser, PhD , Ohio State University Medical Center.
Researchers at Ohio State University Medical Center first put things like pollen and ragweed on the
implements of war of volunteers, and monitored their skin.
"If you don't have an allergy, you're just going to see a little bite of redness temporarily and that'll be
the end of it. But if you're a highly allergic person, you're going to get something called a wheal,"
says Ronald Glaser, PhD, Ohio State University Medical Center.
A welt looks like a bolshie, puffy area, and it tells doctors your hypersensitized. In a relaxed setting the
reactions were normal, but to see how stress would affect those with allergic reactions, experts
asked the volunteers to give a speech- in front of others and into a microphone. As stress levels went
up, the allergic reactions got worse, and in some cases it was 2 to 4 times as bad.
"So the take home message is, if you're allergic, stress and anxiousness are a bad combination," says
Kiecolt-Glaser.
It's a message some 50 million Americans* demand to hear, because the $3.4 billion allergies cost us
every year in this country** is nothing to sneeze at. Experts from Ohio State say anything you can
do to relax and reduce your stress, may end up helping to ease your allergies as well. Things like
massages and meditation could help.
The findings of the study will be presented this month at the American Psychological Association
Meeting in Boston.
*Allergy Facts & Figures, Asthma and Allergy Foundation of America, retrieved August 2008, from http://www.aafa.org
**American Academy of Allergy, Asthma & Immunology, retrieved August 2008 from http://www.aaaai.org
Ohio State University Medical Center
More information
Whether it's being outside about dust or pollen or inside around her friend's cat- thither are times
that Megan Sheasby feels like she just can't escape the grip of her allergies.
"My nose completely clogs up, my throat will sometimes, depending on the type of allergy, close up
as well, marxist, puffy eyes, just selfsame itchy," says Megan.
While it may be Megan's surroundings that trigger her allergies, a new study says it's stress that's
making them worse.
"We found that stress and anxiety create a gravid difference in terms of allergic responses," says Janice
Kiecolt-Glaser, PhD , Ohio State University Medical Center.
Researchers at Ohio State University Medical Center first put things like pollen and ragweed on the
implements of war of volunteers, and monitored their skin.
"If you don't have an allergy, you're just going to see a little bite of redness temporarily and that'll be
the end of it. But if you're a highly allergic person, you're going to get something called a wheal,"
says Ronald Glaser, PhD, Ohio State University Medical Center.
A welt looks like a bolshie, puffy area, and it tells doctors your hypersensitized. In a relaxed setting the
reactions were normal, but to see how stress would affect those with allergic reactions, experts
asked the volunteers to give a speech- in front of others and into a microphone. As stress levels went
up, the allergic reactions got worse, and in some cases it was 2 to 4 times as bad.
"So the take home message is, if you're allergic, stress and anxiousness are a bad combination," says
Kiecolt-Glaser.
It's a message some 50 million Americans* demand to hear, because the $3.4 billion allergies cost us
every year in this country** is nothing to sneeze at. Experts from Ohio State say anything you can
do to relax and reduce your stress, may end up helping to ease your allergies as well. Things like
massages and meditation could help.
The findings of the study will be presented this month at the American Psychological Association
Meeting in Boston.
*Allergy Facts & Figures, Asthma and Allergy Foundation of America, retrieved August 2008, from http://www.aafa.org
**American Academy of Allergy, Asthma & Immunology, retrieved August 2008 from http://www.aaaai.org
Ohio State University Medical Center
More information
Monday, 11 August 2008
The Sonics
Artist: The Sonics
Genre(s):
Rock: Punk-Rock
Discography:
Psycho-Sonic
Year: 1965
Tracks: 29
Maintaining My Cool
Year:
Tracks: 1
Wednesday, 6 August 2008
Thursday, 19 June 2008
Slipknot names new album, preps for tour
NEW YORK (Billboard) - Slipknot's fourth album has been christened "All Hope Is Gone" and will arrive August 26.
A first single and track list for the Roadrunner release have yet to be announced.
"We have made an album that will show the road behind, the road ahead, and where we are as men," group member Corey Taylor said in a statement. "I think it's the best thing I've ever made. And I challenge anyone to prove me wrong."
Taylor previously described the new album to Billboard as a "very dark" cross between "Vol. 3" and 2001's "Iowa." "It has so much power in it and yet there are so many great spots for melody," he said. "It's a controlled chaos that hits you right out of the gate."
Slipknot will co-headline this summer's 30-date Rockstar Energy Drink Mayhem tour, which begins July 9 at the White River Amphitheatre in Auburn, Washington.
Reuters/Billboard
A first single and track list for the Roadrunner release have yet to be announced.
"We have made an album that will show the road behind, the road ahead, and where we are as men," group member Corey Taylor said in a statement. "I think it's the best thing I've ever made. And I challenge anyone to prove me wrong."
Taylor previously described the new album to Billboard as a "very dark" cross between "Vol. 3" and 2001's "Iowa." "It has so much power in it and yet there are so many great spots for melody," he said. "It's a controlled chaos that hits you right out of the gate."
Slipknot will co-headline this summer's 30-date Rockstar Energy Drink Mayhem tour, which begins July 9 at the White River Amphitheatre in Auburn, Washington.
Reuters/Billboard
Monday, 9 June 2008
Liza Minnelli - The Things They Say 8386
"I was in Japan and what I was eating suddenly stood up and walked off the plate. It was some kind of shrimp affair. I've heard of fresh but that is ridiculous." LIZA MINNELLI was not impressed with the menu on a recent visit to the Far East.
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Wednesday, 4 June 2008
R Kelly Seeks Delay In Child Porn Case
Singer R Kelly has requested that his child-pornography trial be delayed citing the "torrent of publicity" surrounding the case over the past weekend.The singer was initially charged with 21 counts of child pornography in 2002 after he supposedly videotaped himself with a girl who was alleged to be 14-years-old. Seven charges have been dropped. Kelly's lawyer, Ed Genson, requested the delay after an article appeared in the Chicago Sun-Times last Saturday (May 3), alleging that a "secret witness" claims she had a three-way with the singer and the reportedly underage girl."We ask to continue the case," Gensen requested. "Because of the torrent of publicity over the weekend."Prosecutors have until Friday to respond to the request with Kelly facing 15 years in jail if convicted.Photo courtesy of Jive Records.
Wednesday, 28 May 2008
Sammy Hagar - Hagar Rules Out Van Halen Reunion Until Eddie Is Sober
SAMMY HAGAR has refused to return to VAN HALEN until band leader EDDIE VAN HALEN proves he's clean and sober.
The reunited original line-up of the rock group was forced to delay comeback dates last year (07) when Van Halen checked himself into rehab for an ongoing alcohol problem.
And then dates on the tour were scrapped earlier this year (08) when the singer was forced to seek further treatment for an undisclosed medical condition.
Now back on the road with his bandmates and his son Wolfgang on bass, Van Halen appears to be in recovery - but former bandmate Hagar is less than convinced.
Hagar was rumoured to be considering rejoining the band to perform hits he sang after original frontman David Lee Roth left the group.
But he has now ruled out a reunion on account of Van Halen's health: "That's just not something I'm really interested in doing again right now.
"Eddie would have to be able to bring himself back to ground zero; by that, I mean he'd have to be completely clean."
And Hagar admits he can't even bring himself to check out the reunited line-up onstage right now: "After the last Van Hagar (sic) tour, Eddie became my enemy; he wasn't the same guy he was when we started the Van Hagar era of the band; he made what should have been a great experience just down right miserable."
"When I say that, I'm talking about the Eddie Van Halen that is struggling with his personal demons... Last time I saw Eddie, he was in really bad shape.
"I did see a recent photo and he looks healthier than he has in a long time. That, to me, is a great thing, Eddie has all the support on the planet from me if he is finally getting his s**t together."
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Saturday, 24 May 2008
Minogue denies Martinez romance
Pop singer Kylie Minogue has denied rumours that she has rekindled her romance with actor Olivier Martinez.
Speaking at the launch of her new bed linen range, the 39-year-old singer dismissed media speculation that she was planning to start a family with Martinez.
Minogue said: "I had dinner with my ex-boyfriend and next thing I know there's a debate about whether we're having a family."
"We didn't even talk about that. As I've maintained, we're friends," she said.
The rumours began after the singer was pictured at Martinez's apartment last Sunday.
The pair were later spotted walking back to Minogue's hotel.
Speaking at the launch of her new bed linen range, the 39-year-old singer dismissed media speculation that she was planning to start a family with Martinez.
Minogue said: "I had dinner with my ex-boyfriend and next thing I know there's a debate about whether we're having a family."
"We didn't even talk about that. As I've maintained, we're friends," she said.
The rumours began after the singer was pictured at Martinez's apartment last Sunday.
The pair were later spotted walking back to Minogue's hotel.
Corrie star named Celeb Mum of the Year
'Coronation Street' star Kym Ryder has been named Celebrity Mum of the Year by Tesco Magazine.
The 31-year-old actress, who plays barmaid Michelle Connor in the soap, has two children, 12-year-old David and 10-year-old Emily.
The actress was reportedly chosen as Celebrity Mum of the Year because of her ability to balance her acting and charity work with her family life.
Ryder said: "I'm shocked and thrilled to have won this award from Tesco Magazine. And I feel humbled to have won alongside such amazing mums, whose stories are truly incredible."
"I'll be bringing lots of tissues to the awards ceremony as I know it will be a really emotional and inspiring day."
The 31-year-old actress, who plays barmaid Michelle Connor in the soap, has two children, 12-year-old David and 10-year-old Emily.
The actress was reportedly chosen as Celebrity Mum of the Year because of her ability to balance her acting and charity work with her family life.
Ryder said: "I'm shocked and thrilled to have won this award from Tesco Magazine. And I feel humbled to have won alongside such amazing mums, whose stories are truly incredible."
"I'll be bringing lots of tissues to the awards ceremony as I know it will be a really emotional and inspiring day."
'Indiana Jones' Sequels Starring Shia LaBeouf? George Lucas 'Can See It Working Out'
He's a professor of archeology, an expert on the occult and a whip-wielding, gun-toting, fist-pounding hero who's never far from the next adventure. Indiana Jones has been called a lot of names since he first exploded onto the big screen in 1981. Now he's about to be called the strangest one of all, hints a Fox News report: sidekick.
While at the Cannes Film Festival, where "Indiana Jones and the Kingdom of the Crystal Skull" is one of many movies premiering out of competition, George Lucas hinted that he's left the door open for more "Indy" stories, but with Shia LaBeouf, not Harrison Ford, at the center of the action.
"I haven't even told Steven [Spielberg] or Harrison this," he was quoted as saying. "But I have an idea to make Shia the lead character next time and have Harrison come back like Sean Connery did in the last movie. I can see it working out."
Connery played Dr. Henry Jones, Indiana's obsessive and somewhat comical father, in "Indiana Jones and the Last Crusade."
Although it has been talked about for months, Lucas' statement is another hint that LaBeouf's character, Mutt, might be Indiana's son — that is, if I remember my SAT analogies correctly (Sean Connery : Indiana :: Indiana : Mutt).
LaBeouf himself seemed keen on sequels when MTV News recently spoke with him about all manner of things "Crystal Skull"-related.
"It all comes down to Harrison. He is Indiana Jones, and there'll never be another Indiana Jones," he said. "[But] I'm so geeked-out by this whole situation. I'd be an extra in any Steven Spielberg movie. So, yeah, of course. I mean, who wouldn't [do another 'Indy']?"
Last year, the Net was flooded with stories claiming that Lucasfilm had signed contracts with both Ford and LaBeouf for additional movies. At the time, a spokesman for the company explicitly denied to MTV News the veracity of these rumors, stating they were just "idle chatter among Internet fans."
Stay tuned to MTV News for more about the possibility of "Indy 5," with breaking news direct from Cannes.
Check out everything we've got on "Indiana Jones and the Kingdom of the Crystal Skull."
For breaking news, celebrity columns, humor and more — updated around the clock — visit MTVMoviesBlog.com.
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Annie Lennox axed by record label
Annie Lennox was reportedly left devastated after she was dropped from her record label and has branded the move a "kick in the teeth".
The former Eurythmics star was reportedly stunned when Sony BMG stopped answering her phone calls just weeks before her contract was due to expire.
Lennox, 53, said she was shocked at the way she was treated by the company which once hailed her as "one of the finest musical voices of the age".
Soundgenerator.com quotes her as saying: "They totally ignored me. It was bizarre. It was a kick in the teeth. They didn't return my phone calls or emails for three weeks. I'm trying to find out what's behind it.
"Probably a good thing I'm no longer with them - mild understatement. Unless it's them trying to tell me something... Hello!"
The singer admitted she has been left contemplating her future in the music industry.
She added: "It feels like I'm spent, as if I've completely run out of energy.
"I'm going to take my time over the coming months to figure out what to do with this freedom."
The former Eurythmics star was reportedly stunned when Sony BMG stopped answering her phone calls just weeks before her contract was due to expire.
Lennox, 53, said she was shocked at the way she was treated by the company which once hailed her as "one of the finest musical voices of the age".
Soundgenerator.com quotes her as saying: "They totally ignored me. It was bizarre. It was a kick in the teeth. They didn't return my phone calls or emails for three weeks. I'm trying to find out what's behind it.
"Probably a good thing I'm no longer with them - mild understatement. Unless it's them trying to tell me something... Hello!"
The singer admitted she has been left contemplating her future in the music industry.
She added: "It feels like I'm spent, as if I've completely run out of energy.
"I'm going to take my time over the coming months to figure out what to do with this freedom."
Daniel Day-Lewis to present DGA award
Wicklow resident Daniel Day-Lewis has been confirmed by the President of the Directors Guild of America, Michael Apted, as one of the presenters at the upcoming DGA awards.
Day-Lewis has been nominated for an Academy Award for Best Actor for his Golden Globe winning role in 'There Will Be Blood'.
This is his fourth nomination for the accolade, which he previously won in 1990 for his performance as Christy Brown in 'My Left Foot'.
Other Oscar nominees who will join Day-Lewis in presenting the DGA awards include: Marion Cotillard, Amy Ryan, Tilda Swinton, Tom Wilkinson, Hal Holbrook and Ellen Page.
'Ocean's Eleven' star Carl Reiner will return as host for the 60th annual DGA awards. This year will mark the 21st time Reiner has hosted the ceremony, which will take place on Saturday 26 January in Los Angeles.
Day-Lewis has been nominated for an Academy Award for Best Actor for his Golden Globe winning role in 'There Will Be Blood'.
This is his fourth nomination for the accolade, which he previously won in 1990 for his performance as Christy Brown in 'My Left Foot'.
Other Oscar nominees who will join Day-Lewis in presenting the DGA awards include: Marion Cotillard, Amy Ryan, Tilda Swinton, Tom Wilkinson, Hal Holbrook and Ellen Page.
'Ocean's Eleven' star Carl Reiner will return as host for the 60th annual DGA awards. This year will mark the 21st time Reiner has hosted the ceremony, which will take place on Saturday 26 January in Los Angeles.
Mute Cyrus sings again
Miley Cyrus returned to the stage for a concert in Florida, but did not say anything about the recent controversy over her Vanity Fair photo portrait. The 15-year-old star of Hannah Montana performed several songs at the Sunday concert.
Nielsen Writes Season Finale
Nielsen closed the books on the 2007-08 broadcast season Wednesday by releasing a list showing how each of the major networks' regular programs fared. Not surprisingly, the top of the list was dominated by the two weekly American Idol telecasts on Fox and the weekly Dancing With the Stars telecasts on ABC that aired on four different nights during the season. Four scripted shows also made it into the top ten: ABC's Desperate Housewives at No. 6; Fox's House at No. 8; CBS's CSI: Crime Scene Investigation at No. 9; and Grey's Anatomy at Number 10. Overall, Fox wound up as the top-rated network for the season, thanks mostly to its American Idol numbers, which averaged 28.75 million on Tuesday nights (No. 1) and 27.78 million on Wednesdays (No. 2). CBS slipped to second place after holding the top spot for the previous five years. Fox was also the only network to improve its ratings this year compared with last year. "What catapulted them is probably that they were the least harmed from the writers strike, '' Brad Adgate, research director at Horizon Media told Bloomberg News. "They had a lot of unscripted shows that were not as impacted, like American Idol.
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