�Reducing levels of uric acid in blood lowered blood press to normal in nearly teens in a study designed to investigate a possible radio link between blood pressure and the chemical, a waste product of the body's normal metabolism, said researchers at Baylor College of Medicine in a account that appears in the current military issue of the Journal of the American Medical Association.
"If you reduce uric acid, at least in some patients, you may be able to reduce blood pressure," said Dr. Daniel Feig, associate professor of pediatrics-renal at BCM and chief of the pediatric hypertension clinics at Texas Children's Hospital. "This could be unitary way hoi polloi develop hypertension and english hawthorn allow us to develop new therapies."
Understanding how people develop high blood pressure gives scientists new tools for understanding the upset and development drugs to prevent and treat it.
Uric acid builds up when the eubstance makes besides much of it or fails to excrete it. It is a waste product resulting from the metabolism of food. Too much uric acid can buoy cause urarthritis, which occurs when uric acid crystals accumulate in the joints. In this study, researchers used allopurinol to tighten high uric acid levels. Allopurinol is usually secondhand to handle gout, merely Feig aforesaid its potentiality side personal effects rule it out as a treatment for high blood pressure.
In the JAMA study, Feig and his colleagues treated teens with newly diagnosed high profligate pressure and elevated levels of uric acid in their parentage with zyloprim. In the study, half of the 30 teen-agers with freshly diagnosed high blood pressing and higher than normal levels of uric acid in their blood underwent treatment with allopurinol twice a clarence Day for four-spot weeks. The other half received a placebo (an inactive do drugs) on the same docket. They then went without either drug for 2 weeks in front receiving the opposite treatment for another four weeks.
The treatment non only reduced uric acid levels, it also reduced blood pressure level in to the highest degree of the teens, aforesaid Feig. In fact, he said, blood pressures reduced to normal in 20 of the 30 teens when they were on allopurinol. By contrast, only 1 of the 30 teens had normal roue pressure when receiving placebo.
"This is far from being a reasonable therapeutic treatment for high blood pressure, but these findings indicate a starting time step in understanding the pathway of the disease," said Feig. "You cannot prevent a disease until you know the drive. This study is way of finding that out."
Studies in rats had indicated previously that high levels of uric acid could be associated with the development of high blood pressure through a proved pathway, said Feig. However, he and his colleagues needed to determine if this was true for humans as well.
"The antihypertensive therapies available to patients are well proven and safe," said Feig. "Currently available antihyperuricemic therapies (treatments that lower uric acidic) are non safe sufficiency to be used as first line therapy for most people with high blood pressure."
Side effects could include nausea, diarrhea, emesis, liver problems and fifty-fifty a selfsame rare, potentially life-threatening reaction known as Steven-Johnson syndrome. While only 1 in 3,000 people develop this problem, the hazard is to a fault great to prescribe the drug on a function basis to people with high stemma pressure, a problem that affects 30 to 35 percent of adults.
Currently uncommitted therapies ar effective but are non solving the problem in everyone. Optimal blood pressures are achieved in only when 40 pct of people who ar treated for the problem. Understanding the cause of high blood pressure could lead to better treatments and level methods of prevention.
Animal studies indicate that early in the disease, the duplicate uric acid activates the renin angiotensin system of the body, shrinking key blood vessels and causing high blood pressure. Eventually, however, the small vessels in the kidney are permanently affected, making the blood air pressure sensitive to salt or sodium. Too much table salt causes the pressure to rise.
Others world Health Organization took part in this work let in Beth Soletsky, RN, also of BCM and Dr. Richard J. Johnson of the University of Florida at Gainesville.
Funding for this work came from the National Institutes of Health.
The full article can be found at http://www.jama.com/.
Source: Glenna Picton
Baylor College of Medicine
More info
Wednesday 10 September 2008
Thursday 21 August 2008
Study: Stress & Anxiety Make Your Allergies Worse
�If you're one of the millions of Americans who suffer from allergies,* this story is for you. Scientists have determined that when it comes to allergies, it's not just things like pets or pollen that are making you woeful it mightiness also be your job or your relationship. A new sketch is proving that in that location is a link between how bad your allergies are, and how practically stress you're under.
Whether it's being outside about dust or pollen or inside around her friend's cat- thither are times
that Megan Sheasby feels like she just can't escape the grip of her allergies.
"My nose completely clogs up, my throat will sometimes, depending on the type of allergy, close up
as well, marxist, puffy eyes, just selfsame itchy," says Megan.
While it may be Megan's surroundings that trigger her allergies, a new study says it's stress that's
making them worse.
"We found that stress and anxiety create a gravid difference in terms of allergic responses," says Janice
Kiecolt-Glaser, PhD , Ohio State University Medical Center.
Researchers at Ohio State University Medical Center first put things like pollen and ragweed on the
implements of war of volunteers, and monitored their skin.
"If you don't have an allergy, you're just going to see a little bite of redness temporarily and that'll be
the end of it. But if you're a highly allergic person, you're going to get something called a wheal,"
says Ronald Glaser, PhD, Ohio State University Medical Center.
A welt looks like a bolshie, puffy area, and it tells doctors your hypersensitized. In a relaxed setting the
reactions were normal, but to see how stress would affect those with allergic reactions, experts
asked the volunteers to give a speech- in front of others and into a microphone. As stress levels went
up, the allergic reactions got worse, and in some cases it was 2 to 4 times as bad.
"So the take home message is, if you're allergic, stress and anxiousness are a bad combination," says
Kiecolt-Glaser.
It's a message some 50 million Americans* demand to hear, because the $3.4 billion allergies cost us
every year in this country** is nothing to sneeze at. Experts from Ohio State say anything you can
do to relax and reduce your stress, may end up helping to ease your allergies as well. Things like
massages and meditation could help.
The findings of the study will be presented this month at the American Psychological Association
Meeting in Boston.
*Allergy Facts & Figures, Asthma and Allergy Foundation of America, retrieved August 2008, from http://www.aafa.org
**American Academy of Allergy, Asthma & Immunology, retrieved August 2008 from http://www.aaaai.org
Ohio State University Medical Center
More information
Whether it's being outside about dust or pollen or inside around her friend's cat- thither are times
that Megan Sheasby feels like she just can't escape the grip of her allergies.
"My nose completely clogs up, my throat will sometimes, depending on the type of allergy, close up
as well, marxist, puffy eyes, just selfsame itchy," says Megan.
While it may be Megan's surroundings that trigger her allergies, a new study says it's stress that's
making them worse.
"We found that stress and anxiety create a gravid difference in terms of allergic responses," says Janice
Kiecolt-Glaser, PhD , Ohio State University Medical Center.
Researchers at Ohio State University Medical Center first put things like pollen and ragweed on the
implements of war of volunteers, and monitored their skin.
"If you don't have an allergy, you're just going to see a little bite of redness temporarily and that'll be
the end of it. But if you're a highly allergic person, you're going to get something called a wheal,"
says Ronald Glaser, PhD, Ohio State University Medical Center.
A welt looks like a bolshie, puffy area, and it tells doctors your hypersensitized. In a relaxed setting the
reactions were normal, but to see how stress would affect those with allergic reactions, experts
asked the volunteers to give a speech- in front of others and into a microphone. As stress levels went
up, the allergic reactions got worse, and in some cases it was 2 to 4 times as bad.
"So the take home message is, if you're allergic, stress and anxiousness are a bad combination," says
Kiecolt-Glaser.
It's a message some 50 million Americans* demand to hear, because the $3.4 billion allergies cost us
every year in this country** is nothing to sneeze at. Experts from Ohio State say anything you can
do to relax and reduce your stress, may end up helping to ease your allergies as well. Things like
massages and meditation could help.
The findings of the study will be presented this month at the American Psychological Association
Meeting in Boston.
*Allergy Facts & Figures, Asthma and Allergy Foundation of America, retrieved August 2008, from http://www.aafa.org
**American Academy of Allergy, Asthma & Immunology, retrieved August 2008 from http://www.aaaai.org
Ohio State University Medical Center
More information
Monday 11 August 2008
The Sonics
Artist: The Sonics
Genre(s):
Rock: Punk-Rock
Discography:
Psycho-Sonic
Year: 1965
Tracks: 29
Maintaining My Cool
Year:
Tracks: 1
Wednesday 6 August 2008
Thursday 19 June 2008
Slipknot names new album, preps for tour
NEW YORK (Billboard) - Slipknot's fourth album has been christened "All Hope Is Gone" and will arrive August 26.
A first single and track list for the Roadrunner release have yet to be announced.
"We have made an album that will show the road behind, the road ahead, and where we are as men," group member Corey Taylor said in a statement. "I think it's the best thing I've ever made. And I challenge anyone to prove me wrong."
Taylor previously described the new album to Billboard as a "very dark" cross between "Vol. 3" and 2001's "Iowa." "It has so much power in it and yet there are so many great spots for melody," he said. "It's a controlled chaos that hits you right out of the gate."
Slipknot will co-headline this summer's 30-date Rockstar Energy Drink Mayhem tour, which begins July 9 at the White River Amphitheatre in Auburn, Washington.
Reuters/Billboard
A first single and track list for the Roadrunner release have yet to be announced.
"We have made an album that will show the road behind, the road ahead, and where we are as men," group member Corey Taylor said in a statement. "I think it's the best thing I've ever made. And I challenge anyone to prove me wrong."
Taylor previously described the new album to Billboard as a "very dark" cross between "Vol. 3" and 2001's "Iowa." "It has so much power in it and yet there are so many great spots for melody," he said. "It's a controlled chaos that hits you right out of the gate."
Slipknot will co-headline this summer's 30-date Rockstar Energy Drink Mayhem tour, which begins July 9 at the White River Amphitheatre in Auburn, Washington.
Reuters/Billboard
Monday 9 June 2008
Liza Minnelli - The Things They Say 8386
"I was in Japan and what I was eating suddenly stood up and walked off the plate. It was some kind of shrimp affair. I've heard of fresh but that is ridiculous." LIZA MINNELLI was not impressed with the menu on a recent visit to the Far East.
See Also
Wednesday 4 June 2008
R Kelly Seeks Delay In Child Porn Case
Singer R Kelly has requested that his child-pornography trial be delayed citing the "torrent of publicity" surrounding the case over the past weekend.The singer was initially charged with 21 counts of child pornography in 2002 after he supposedly videotaped himself with a girl who was alleged to be 14-years-old. Seven charges have been dropped. Kelly's lawyer, Ed Genson, requested the delay after an article appeared in the Chicago Sun-Times last Saturday (May 3), alleging that a "secret witness" claims she had a three-way with the singer and the reportedly underage girl."We ask to continue the case," Gensen requested. "Because of the torrent of publicity over the weekend."Prosecutors have until Friday to respond to the request with Kelly facing 15 years in jail if convicted.Photo courtesy of Jive Records.
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